个人简介
教育经历:
2009.09 -- 2013.06 南京工业大学,学士,生物工程
2013.09 -- 2018.12 南京工业大学,博士,硕博连读,生物化工,导师:应汉杰院士
工作经历:
2023.01 -- 至今 南京工业大学,生物与制药工程学院,副教授
2019.01 -- 2022.12 南京工业大学,生物与制药工程学院,师资博士后 合作导师: 欧阳平凯院士
研究方向:
利用酶工程、有机合成化学、合成生物学等多学科交叉,围绕多酶级联催化、化学酶级联催化、辅因子工程等方向进行研究,开展(1)酶及辅酶元件的理性、半理性设计及定向进化;(2)多酶催化、化学酶级联催化过程设计、优化强化、机制解析及应用等相关工作。
代表性成果
获奖情况:
2019年,中国生物工程学会,第十三届学术年会青年优秀论文奖,二等奖
2019年,南京工业大学优秀博士学位论文
承担项目:
主持国家自然科学青年基金(在研),江苏省自然科学基金青年项目(在研),中国博士后科学基金会面上项目一等资助各1项(已结题),参与国家自然科学基金面上项目1项。
代表性论文:
1. Tan Zhuotao, Zhang Xiaowang, Xu Mengjiao, Fu Yaping, Zhuang Wei, Li Ming, Wu Xiaojin, Ying Hanjie, Ouyang Pingkai, Zhu Chenjie, Cooperative Chemoenzymatic Synthesis of N-heterocycles via Synergizing Bio- with Organocatalysis, Science Advances, 2022, 8, eadd1912.
2. Tan Zhuotao, Zhu Chenjie, Fu Jingwen, Zhang xiaowang, Li Ming, Zhuang Wei, Ying Hanjie, Regulating Cofactor Balance In Vivo with a Synthetic Flavin Analogue, Angewandte Chemie International Edition, 2018, 57, 16464.
3. Tan Zhuotao, Han Yaoying, Fu Yaping, Zhang Xiaowang, Xu Mengjiao, Na Qi, Zhuang Wei, Qu Xudong, Ying Hanjie, Zhu Chenjie, Investigating the Structure-Reactivity Relationships Between Nicotinamide Coenzyme Biomimetics and Pentaerythritol Tetranitrate Reductase, Advanced Synthesis & Catalysis, 2021, 364, 103.
4. Qi Siyu, Tan Zhuotao*, Na Qi, Zhang Xiaowang, Xu Mengjiao, Zhuang Wei, Li Ming, Ying Hanjie, Ouyang Pingkai, Zhu, Chenjie*, Constructing a Multienzyme Cascade Redox-neutral System for the Synthesis of Halogenated Indoles, Chemical Communications, 2022, 58, 6016.
5. Xu Mengjiao, Tan Zhuotao, Zhu Chenjie, Zhuang Wei, Ying Hanjie, Ouyang Pingkai, Recent Advance of Chemoenzymatic Catalysis for the Synthesis of Chemicals: Scope and Challenge, Chinese Journal of Chemical Engineering, 2021, 30, 146-167.
6. Zhang Xiaowang, Tan Zhuotao, Li Chaojian, Qi Siyu, Xu Mengjiao, Li Ming, Xiong Wenlong, Zhuang Wei, Liu Dong, Zhu Chenjie, Hanjie Ying, Biosynthesis of Lactones from Diols Mediated by an Artificial Flavin, Bioresources and Bioprocessing, 2021, 8, 1.
7. Tan Zhuotao, Ma Hongmin, Li Qing, Pu Lingling, Cao Yang, Qu Xudong, Zhu chenjie, Ying Hanjie, Biosynthesis of Optically Pure Chiral Alcohols by a Substrate Coupled and Biphasic System with a Short-chain Dehydrogenase from Streptomyces griseus, Enzyme and Microbial Technology, 2016, 93, 191.
8. 谭卓涛,付静雯,张肖旺,韩耀颖,付亚萍,朱晨杰,应汉杰, 桥联黄素再生NAD+耦联L-谷氨酸脱氢酶高效产α-酮戊二酸,生物加工过程,2021, 19, 136.