主讲课程

本科生：《生物化学》、《生物工艺学》、《生工类专业论文写作》

本科生创新创业指导：本科生创新创业项目“一步酶法生物合成微分子量葡聚糖”并获校优秀作品奖；2021年获批1项大学生“优培计划”项目

研究生：《学科科技英语写作》、《实用微生物技术》

研究生创新创业指导：研究生创新创业项目“聚糖成材——葡聚糖大健康守护纪元开拓者”，并获中国国际大学生创新大赛（2025）金奖

个人简介

马江锋，教授，博导，江苏省“333高层次人才培养工程”培养对象，主要从事合成生物学、发酵工程和中医现代化相关研究，以工业微生物和酶为研究对象，设计和构建以产品为导向、绿色节能的生物催化和应用体系，实现有机酸、氨基酸、功能性糖及其衍生物的规模化制备及其在中医外用制剂中的应用。其中作为负责人全程参与了中石化扬子石化1000吨/年厌氧固定CO₂发酵制备生物基丁二酸产业化项目的基础设计、详细设计和开车运行，作为负责人完成了常茂生物工程股份有限公司5000吨L-天冬氨酸项目的技术和生产线改造，具有丰富的工程化实践经验。

近5年在国内外刊物上共发表论文68篇，其中SCI论文66篇，申请发明专利28件，授权发明专利11件，获教育部、江苏省等省部级技术发明二等奖3项。参编专著《生物基高分子材料》《非粮生物质炼制技术》；参译英文经典教材《图解生物技术》。作为负责人承担国家自然科学基金面上项目、国家重点研发计划子课题、江苏省重点研发计划和中国-德国联邦教研部(BMBF)国际合作项目等项目10余项。

近五年主要承担的科研项目：

2024~2029，维生素的高效异源合成，国家重点研发项目子课题，子课题负责人

2022~2025，葡聚糖/疮灵液复合水凝胶创制治疗慢性难愈性创疡的多中心研究（BE2022819），江苏省重点研发计划，课题负责人

2022~2025，大肠杆菌细胞膜磷脂系统重构实现低pH电合成琥珀酸研究（22178175），国家自然科学基金面上项目，项目负责人

2019~2024，非天然利用甲醇人工细胞的创建及应用（2018YFA0901500），国家重点研发计划子课题，子课题负责人

2022~2024，医工结合葡聚糖青敷复合水凝胶的制备及其功效研究，江苏省中医药局项目，课题负责人

2025，南京建昌水产基于葡聚糖类寡糖的调土养土-调水养水新技术的产学研合作应用成果项目，横向课题，项目负责人

2024，丙氨酸生产菌株的生物信息学研究，横向课题，项目负责人

2024，一种提高牦牛骨粉游离钙含量的方法及其微生物，横向课题，项目负责人

2024，一株产L-苹果酸生产菌株的构建，横向课题，项目负责人

2023，一种微分子量葡聚糖的生产方法，横向课题，项目负责人

近五年代表性成果

1. Jiangfeng Ma*, et al. Domain engineering of dextransucrase and soft nanoconfinementenhanced biosynthesis of pharmaceutical-grade dextran. International Journal of Biological Macromolecules, 2025, 319: 145257.

2. Jiangfeng Ma*, et al. Characterization of a Novel Mutansucrase (MUT-I) from Leuconostoc pseudomesenteroides G29: Enzymatic Properties and Product Analysis. Journal of Agricultural and Food Chemistry, 2025, 73: 30777−30790.

3. Jiangfeng Ma*, et al. Dextran based dual-dynamic-network hydrogel for chronic wound healing with mechanically adaptive, antibacterial, and pH-responsive drug delivery. International Journal of Biological Macromolecules, 2025, 322: 144865.

4. Jiangfeng Ma*, et al. Durable and impermeable cement-based material crack repair via MICP: synergistic effects of bio-polymeric additives and repeated repairs. Journal of Materials in Civil Engineering, 2025.

5. Jiangfeng Ma*, et al. From kinetics to synergy: Elucidating the action characterization of GH5 processive endoglucanase M3-1. International Journal of Biological Macromolecules, 2025, 306: 141451.

6. Jiangfeng Ma*, et al. Complementary Distant and Active Site Mutations Simultaneously Enhance Catalytic Activity and Thermostability of α-Galactosidase. Journal of Agricultural and Food Chemistry, 2025, 73: 3635-3644.

7. Jiangfeng Ma*, et al. Underlying mechanism of traditional herbal formula Chuang-Ling-Ye in the treatment of diabetic foot ulcer through network pharmacology and molecular docking. Current Pharmaceutical Design, 2024, 439: 140837.

8. Jiangfeng Ma*, et al. An eco-friendly process for low-degree polymerization xylo-oligosaccharides production from corncob via enzyme adsorption-hydrolysis integrated approach by reconstructing fusion protein. Journal of Cleaner Production, 2024, 439: 140837.

9. Jiangfeng Ma*, et al. Preparation and characterization of a novel morphosis of dextran and its derivatization with polyethyleneimine. Molecules, 2023, 28: 7210.

10. Jiangfeng Ma*, et al. Membrane engineering of Escherichia coli based on “Building bridges” and “Digging tunnels” to improve electro-fermentation of succinate. Bioelectrochemistry, 2023, 152: 108455.

11. Jiangfeng Ma*, et al. Cofactor metabolic engineering of Escherichia coli for aerobic L-malate production with lower CO₂ emissions. Bioengineering-Basel, 2023, 10: 881.

12. Jiangfeng Ma*, et al. Microbial fuel cell-assisted utilization of glycerol for succinate production by mutant of Actinobacillus succinogenes. Biotechnology for Biofuels, 2021, 14: 23.

13. Jiangfeng Ma*, et al. Production and characterization of insoluble α-1,3-linked glucan and soluble α-1,6-linked dextran from Leuconostoc pseudomesenteroides G29. Chinese Journal of Chemical Engineering, 2021, 39: 211-218.

14. Jiangfeng Ma*, et al. Low molar mass dextran: One-step synthesis with dextransucrase by site-directed mutagenesis and its potential of iron-loading. Frontiers in Bioengineering and Biotechnology, 2021, 9:747602.

15. Jiangfeng Ma*, et al. A staged representation electrochemical stimulated strategy to regulate intracellular reducing power for improving succinate production by Escherichia coli AFP111. Biotechnology Journal, 2021, 2000415.

16. Jiangfeng Ma*, et al. Microbial production of L-malate from renewable non-food feedstocks. Chinese Journal of Chemical Engineering, 2021, 30: 105-111.

17. Jiangfeng Ma*, et al. Metabolic engineering of Escherichia coli for L-malate production anaerobically. Microbial Cell Factories, 2020, 19:165.

18. Jiangfeng Ma*, et al. Progress and prospects of bioelectrochemical systems: Electron transfer and its applications in the microbial metabolism. Frontiers in Bioengineering and Biotechnology, 2020, 8:10.

19. Jiangfeng Ma*, et al. Novel biosynthesis of L-malate based on overflow metabolism in Escherichia coli. Biochemical Engineering Journal, 2019, 149:107255.

20. Jiangfeng Ma*, et al. Identification and characterization of a thermostable GH11 xylanase from Paenibacillus campinasensis NTU-11 and the distinct roles of its carbohydrate-binding domain and linker sequence. Colloids and Surfaces B: Biointerfaces, DOI: 10.1016/j.colsurfb.2021.112167

近5年授权和转让专利：

1. 一株利用木质纤维素水解液厌氧发酵产L-天冬氨酸的基因工程菌及其构建方法与应用，ZL 201710355267.6

2. 一株高效转化延胡索酸为L-天冬酰胺的重组大肠杆菌及其构建方法与应用，ZL 201610430229.8

3. 一种高粘度微分子量葡聚糖的生产方法，ZL 201610951475.8

4. 一株利用单糖发酵产L-天冬氨酸的基因工程菌及其构建方法与应用，ZL 201510822797.8

5. 一种低聚果糖的纯化方法，ZL 201410232931.4（已转让）