主讲课程

《系统生物学与合成生物学》、《基因工程药物》和《酶工程》

个人简介

张阿磊，男，1993年，副教授，硕士生导师，生物化工博士，师从欧阳平凯院士。主要研究方向为以酶催化技术转化低值含氮大分子（甲壳素、硝化纤维素等）合成高值含氮化学品如材料单体、功能糖等，涉及酶挖掘、酶改造及酶催化过程强化等技术。以第一/通讯作者在生物化工领域权威期刊Green Chemistry、Chemical Engineering Journal、Carbohydrate Polymers、 Biotechnology For Biofuels等发表SCI论文30余篇，中国发明专利授权8件。

个人经历

1.2013-09至2015-12,南京工业大学,生物化工,博士（导师欧阳平凯院士）

2.2018-07至2020-12，南京工业大学,博士后（合作导师陈可泉教授）

3.2021-03至今,南京工业大学,生物与制药工程学院,副教授

代表性成果

指导学生获奖

指导本科生全国大学生生命科学创新创业大赛国家三等奖，获指导教师三等奖。

指导“互联网+”创新创业大赛江苏省三等奖和校级二等奖。

指导本科生校级大创项目6项。

指导研究生获得校级奖学金3人次。

代表性项目：

近五年主持国家自然科学面上基金、国家自然科学青年基金、国家重点研发计划合成生物学专项子课题、江苏省农科院自主创新资金、中国博士后特别资助和面上（一等）等8项国家和省部级课题。

代表性论文：

1. Zhang Alei*, et.al. Self-sufficient biocatalysts constructed using chitin-based microspheres. Chemical Engineering Journal, 2023, Accepted.

2. Zhang Alei, et al. Efficient enzymatic hydrolysis of chitin into N-acetyl glucosamine using alkali as a recyclable pretreatment reagent. Green Chemistry, 2021-05-01, 23:8, 3081-3089.

3. Zhang Alei*, et.al. Chitin biopolymer mediates self-sufficient biocatalyst of pyridoxal 5'-phosphate and L-lysine decarboxylase. Chemical Engineering Journal, 2021, 427.

4. Zhang, Alei, et al. Enzymatic hydrolysis of chitin pretreated by bacterial fermentation to obtain pure N-acetyl-D-glucosamine. Green Chemistry. 2018, 20 (10): 2320-2327.

5. Zhang Alei, et.al. An efficient enzymatic production of N-acetyl-D-glucosamine from crude chitin powders. Green Chemistry. 2016, 18 (7): 2147-2154.

6.Wei, Guoguang^#; Zhang, Alei^#, et al. Enzymatic production of N-acetyl-D-glucosamine from crayfish shell wastes pretreated via high pressure homogenization. Carbohydrate Polymers. 2017, 171: 236-241.

7. Zhang, Alei, et al. Molecular characterization of a novel chitinase CmChi1 from Chitinolyticbacter meiyuanensis SYBC‑H1 and its use in N‑acetyl‑D‑glucosamine production. Biotechnology for biofuels. 2018, 11:79.

8. Zhang, Alei, et al. A novel bacterial beta-N-acetyl glucosaminidase from Chitinolyticbacter meiyuanensis possessing transglycosylation and reverse hydrolysis activities. Biotechnology for Biofuels, 2020, 13:1.

9. Zhang, Alei, Mo, Xiaofang, Zhou, Ning, et al. Identification of Chitinolytic Enzymes in Chitinolyticbacter meiyuanensis and Mechanism of Efficiently Hydrolyzing Chitin to N-Acetyl Glucosamine. Frontier in Microbiology. 2020, 11 572053.

10. Zhang Alei*, et al. Effect of organic solvents treatment on structure of chitin and its enzymatic hydrolysis. Polymer Degradation and Stability, 2022, 198.