主讲课程

本科生课程《生物工程制图》、《生物技术法律》

研究生课程《生物过程工程》

个人简介

李辉，教授，博士生导师。研究方向为生物过程工程及过程强化。主持国家自然科学基金面上项目、青年项目，国家重点研发计划“绿色生物制造”青年任务，江苏省高等学校自然科学项目等纵向项目，与中国海油集团、甘肃银光聚银、江苏百仑等多家企业开展项目合作。以第一作者/通讯作者在Angewandte Chemie International Edition, Engineering, Chemical Engineering Journal, Bioresource Technology, Separation and Purification Technology, Chemical Engineering Science, Industrial & Engineering Chemistry Research, ACS Applied Materials & Interfaces等权威期刊发表SCI论文40余篇，第一发明人授权中国发明专利6件。

现阶段的主要研究方向包括：

（1）微界面强化生物反应过程与智能化

（2）微环境调控的酶固定化与催化强化

（3）生物基材料单体分离纯化与衍生化

代表性成果

主要科研项目

1）国家自然科学基金面上项目，多催化中心光活性人工金属酶的构建及协同调控，22378200，2024/01-2027/12，在研，主持；

2）国家重点研发计划“绿色生物制造”青年项目，面向手性药物合成的多酶体系构建与机制研究，2021YFC2104100，2021/12-2024/11，已结题，任务负责人；

3）国家自然科学基金青年项目，自组装纳米人工金属酶的设计及苄基胺快速动态动力学拆分的研究，21706126，2018/01- 2020/12，已结题，主持；

4）企业委托项目，50L生物反应器的CFD模拟，2025/11-2025/12，已结题，主持；

5）企业委托项目，生物基二胺生产技术开发及下游产品应用研究，2022/05-2023/03，已结题，主持；

6）企业委托项目，PDI异氰尿酸酯三聚体转化效率的解析及催化剂开发，2020/12-2021/07，已结题，主持。

代表性论文

1）Hui Li*, et al. Continuous-Flow Modular Reactor with a Chiral Microenvironment Enhances the Biocatalytic Synthesis of Norepinephrine. Angewandte Chemie International Edition, 2026, e14462.

2）Hui Li*, et al. Enhanced mixing and mass transfer of non-Newtonian fluids for DHA production via Schizochytrium sp. fermentation. Bioresource Technology, 2025, 438, 133264.

3）Hui Li*, et al. Influence of inorganic impurities in fermentation broth on the crystallization mechanism of co-produced bio-based cadaverine succinate: Experimental and molecular simulations. Journal of Environmental Chemical Engineering, 2025, 13, 117335.

4）Hui Li*, et al. Establishment of CFD-ANN-NSGA-II model for stirred reactor design. Chemical Engineering Science, 2025, 311, 121614.

5）Hui Li*. Protein aggregates facilitated by polar aprotic solvents as carriers for enzyme immobilization. International Journal of Biological Macromolecules, 2025, 307, 14216.

6）Hui Li*, et al. Enhancing CO₂ capture efficiency: CFD investigation of gas–liquid self-suction reactor configurations. Separation and Purification Technology, 2025, 360, 130979.

7）Hui Li. Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems. Industrial & Engineering Chemistry Research, 2024, 63, 13801-13813.

8）Hui Li*, et al. Reducing High-Molecular-Weight Oligomers in Biobased Pentamethylene Diisocyanate Trimers. Industrial & Engineering Chemistry Research, 2024, 63, 10482-10491.

9）Hui Li*, et al. Bubble Diameter, Mass Transfer, and Bioreaction of Dynamic Membrane-Stirred Reactors. Industrial & Engineering Chemistry Research, 2024, 63, 1760-1772.

10）Hui Li*. Photocoupling multi-enzyme nanoreactor simultaneously synthesizes pentanediamine and formic acid. Chemical Engineering Journal, 2024, 481, 148419.

11）Hui Li. Artificial neural network and genetic algorithm coupled fermentation kinetics to regulate L-lysine fermentation. Bioresource Technology, 2024, 393, 130151.

12）Hui Li*. Promotion of CO₂ reduction in a nanophotocatalyst by hydrogen peroxide. Separation and Purification Technology, 2023, 311, 123206.

13）Hui Li*. Inert enzyme nanoaggregates for simultaneous biodecarboxylation and CO₂ conversion. Separation and Purification Technology, 2023, 305,122447.

14）Hui Li*, et al. Mass Transfer, Gas Holdup, and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor. Engineering, 2022, 13, 153-163.

15）Hui Li*, et al. Synthesis, Monomer Removal, Modification, and Coating Performances of Biobased Pentamethylene Diisocyanate Isocyanurate Trimers. Industrial & Engineering Chemistry Research, 2022, 61, 2403−2416.

16）Hui Li. Hierarchical porous and hydrophilic metal-organic frameworks with enhanced enzyme activity. Chemical Communications, 2020, 56, 4724-4727.

17）Hui Li. Artificial Nanometalloenzymes for Cooperative Tandem Catalysis. ACS Applied Materials & Interfaces, 2019, 11, 15718-15726.

18）Hui Li, et al. Hydrodynamics, mass transfer and cell growth characteristics in a novel microbubble stirred bioreactor employing sintered porous metal plate impeller as gas sparger. Chemical Engineering Science, 2018, 192, 665-677.

第一发明人授权发明专利

1）一种三层自吸搅拌式反应器，ZL202310459506.8

2）一种自吸曝气结构的气升式反应器，ZL202210012952.X

3）一种利用二价金属离子与组氨酸标签纯化并固定化蛋白的方法及其应用，ZL202110340236.X

4）一种合成蛋白骨架纳米材料的方法及其在固定化酶上的应用，ZL202111649442.5

5）一种多酶连体纳米反应器的制备方法及其在同步合成上的应用，ZL202110453185.1

6）一种光活性人工细胞的构建方法及其在同步绿色合成戊二胺和甲酸上的应用，ZL202110693907.0