主讲课程

《分子生物学》、《系统生物学与合成生物技术》

个人简介

2015年于天津大学获得博士学位，同年加入南京工业大学生物与制药工程学院。主要从事生物催化工程和合成生物学领域研究工作：（1）碳一原料（甲醇、CO₂）的生物转化；（2）二元胺、多元醇生产菌株的代谢工程改造和调控；（3）多酶催化合成氨基酸衍生物、含能材料、健康化学品等。荣获“333高层次人才培养工程第三层次”、“江苏省低碳技术学会拔尖青年科学家”、“南太湖精英计划创新领军人才”等荣誉称号。

代表性成果

荣誉获奖（含指导学生获奖）：

2019年，入选湖州市“南太湖精英计划”创新领军人才

2019年，荣获南京工业大学保密工作先进个人

2020年，入选江苏省低碳技术学会“拔尖青年科学家”

2020年，荣获南京工业大学第十一届青年教师授课竞赛二等奖

2020年，指导本科生获大学生创新创业大赛项目国家级立项

2021年，指导本科生获大学生创新创业大赛项目国家级立项

2021年，指导研究生获江苏省研究生科研创新项目1项

2021年，指导研究生“科创江苏”创新创业大赛一等奖

2022年，指导研究生获中国“互联网+”大学生创新创业大赛省二等奖

2022年，入选江苏省第六期“333工程”第三层次培养对象

代表性论文：

1. Xin Wang*. A novel co-production of cadaverine and succinic acid based on a thermal switch system in recombinant Escherichia coli. Microbial cell factories, 2022. 21:248

2. Xin Wang*. Enhancing Soluble Expression of Phospholipase B for Efficient Catalytic Synthesis of L-Alpha-Glycerylphosphorylcholine, 2022, Catalysis., 12(6): 650.

3. Xin Wang*. The biosynthesis of D-1,2,4-butanetriol from D-arabinose with an engineered Escherichia coli, 2022, Front. Bioeng. Biotechnol., 10:8844517.

4. Xin Wang*. Design of an in vitro multienzyme cascade system for the biosynthesis of nicotinamide mononucleotide. Catalysis Science & Technology. 2022, 12, 1080.

5. Xin Wang*. Characterization and application of a recombinant dopa decarboxylase from Harmonia axyridis for the efficient biosynthesis of dopamine, 2022. Chinese Journal of Chemical Engineering, 41:449-456.

6. Xin Wang* .Methylotrophy of Pichia pastoris: Current Advances, Applications, and Future Perspectives for Methanol-Based Biomanufacturing,2022.ACS Sustainable Chemistry & Engineering ,10 (5):1741-1752.

7. Xin Wang*. β-Alanine production by L-aspartate-α-decarboxylase from Corynebacterium glutamicum and variants with reduced substrate inhibition, 2022. Molecular Catalysis, 522: 112246.

8. Xin Wang. Methanol Assimilation with CO₂ Reduction in Butyribacterium methylotrophicum and Development of Genetic Toolkits for Its Engineering, ACS sustainable Chemistry & Engineering, 2021.

9. Xin Wang. Ameliorating end-product inhibition to improve cadaverine production in engineered Escherichia coli and its application in the synthesis of bio-based diisocyanates, Synthetic and Systems Biotechnology, 2021, 6(4):243-253.

10. Xin Wang. The production of biobased diamines from renewable carbon sources: current advances and perspectives. Chinese Journal of Chemical Engineering, 2021. 30: 4-13.

11. Xin Wang*. A two-enzyme cascade system for the bio-production of spermidine from putrescine. Molecular Catalysis, 2021. 504(1): 111439.

12. Xin Wang*, Engineering prokaryotic regulator IrrE to enhance stress tolerance in budding yeast, Biotechnology for Biofuels, 2020. 13(1):193.

13. Xin Wang*. Efficient production of cyclic adenosine monophosphate from adenosine triphosphate by the N-terminal half of adenylate cyclase from Escherichia coli, Chinese Journal of Chemical Engineering, 2020. 28(8): 2167–2172.

14. Xin Wang*, Chen Kequan, and Ouyang Pingkai. Highly efficient extracellular production of recombinant Streptomyces PMF Phospholipase D in Escherichia coli, 2020.Catalysts, 10(9): 1–15.

15. Xin Wang. 2019. Methanol fermentation increases the production of NAD(P)H-dependent chemicals in synthetic methylotrophic Escherichia coli, Biotechnology for Biofuels, 12(1): 1–11.

16. Xin Wang. Engineering a microbial consortium based whole-cell system for efficient production of glutarate from L-lysine, Frontiers in Microbiology. 2019. 10: 341.

17. Xin Wang*. β-Alanine production using whole-cell biocatalysts in recombinant Escherichia coli, Molecular Catalysis, 2018. 449: 93–98.

18. Xin Wang. D-1,2,4-Butanetriol production from renewable biomass with optimization of synthetic pathway in engineered Escherichia coli, Bioresource Technology, 2017. 250: 406–412.

19. Xin Wang*. Process optimization for enhancing production of cis-4-hydroxy-l-proline by engineered Escherichia coli, Microbial cell factories, 2017. 16(1): 210.

20. Xin Wang. Efficient production of enantiopure D-lysine from L-lysine by a two-enzyme cascade system, Catalysts, 2016. 6(11): 618-630 .

21. Xin Wang. Efficient production of 5-aminovalerate from L-lysine by engineered Escherichia coli whole-cell biocatalysts, J MOL CATAL B-ENZYM, 2016. 134: 115-121